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Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, et al

Given that DAB2IP has been demonstrated to effectively inhibit key pro-inflammatory signaling pathways such as NF-B and TNF, we speculate that DAB2IP may, through its anti-inflammatory function, negatively regulate the formation and development of tertiary lymphoid organs within plaques, thereby mitigating abnormal local immune responses

Common adverse effects include insomnia, dry mouth, dizziness, and elevated blood pressure

Stough, C

doi: 10.1200/JCO.2011.39.3652 38 BaulchJELiMRaabeOG

Finally, centrifuged at 10,000 g for 10 min at room temperature, and transferred 200 L of the supernatant to a 96-well plate for detection using a microplate reader (ThermoFisher Scientific, USA)