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The future role and position of insulins in the T2D treatment continuum will need to be reconsidered, given incretin-based therapies provide substantial reduction in HbA1c without the potential for weight gain and hypoglycaemia seen with insulins

They also participate in endogenous cellular metabolism [13] by functioning as glutathione peroxidases (GPOXs) that counteract oxidative stress, as flavonoid-binding proteins [7], as stress-signalling proteins [14], and in regulating apoptosis [15]

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Several small studies using GHK-Cu serums with microneedling report additive skin-texture improvements