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Epigenetic modifications, such as DNA methylation, histone acetylation, lactylation, and RNA m6A and m5C modifications, are considered crucial in the occurrence of HGSOC and drug resistance ( Oncolytic virus therapy, an emerging cancer treatment approach, has garnered widespread attention in HGSOC research

Lieske and Myers 1994

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) Specifically, the changes to the gut microbiome composition caused a reduction in the intestinal cells that produce mucin, which is the barrier that prevents microbes from causing inflammation in the gut

Scientific Monthly