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To efficiently explore this chemically diverse space, we developed a HTS framework that integrates ML with DFT calculations

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In a retrospective review of 64 patients with metastatic melanoma treated with Nivolumab plus Ipilimumab, 31 patients experienced early toxicity warranting discontinuation of treatment, and 4 of these (13%) further developed a significant irAEs 4 months after treatment cessation

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