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PMID 10874275

Several studies of HCC cells have shown that inhibition of NFE2L2 expression can increase the anticancer activity of the chemicals erastin and sorafenib, with inhibition of NFE2L2 inducing ferroptosis and killing HCC cells (64)

doi: 10.3389/fimmu.2022.986847 Received 05 July 2022 Accepted 08 September 2022 Published 23 September 2022 Volume 13 - 2022 Edited by Keiji Hirota, Kyoto University, Japan Reviewed by Michihito Kono, Hokkaido University, Japan

Both untreated samples (containing GSH and GSSG) and 2-VP treated samples (containing GSSG) were assessed by the DTNB assay in parallel

2 The global burden of IHD: incidence, prevalence, and mortality Cardiovascular diseases account for 32% of all global deaths, with an estimated 19.8 million deaths annually, and 85% of these deaths are attributed to IHD and stroke (WHO, 2017)