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Tanshinone IIA (TIIA) enhances NRF2 binding and transcriptional activation at the promoters of target transporter proteins BSEP and NTCP through TET2-mediated demethylation of NRF2

Mayatepek E, Badiou S, Bellet H, Lehmann WD: A patient with neurological symptoms and abnormal leukotriene metabolism: a new defect in leukotriene biosynthesis

These data indicate that genes associated with metabolic ROS generation tend to be upregulated in MZB compared to FoB, suggesting that differences in the control of ROS signaling might contribute to the classical distinctions between these two mature B cell subsets