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Modeling threonine in the same orientation as serine onto the active site would induce clashes between the threonine methyl group and the Cys residues, forcing threonine into a less productive conformation for activation (Bilokapic et al

DCPIP reduction performed superiorly to FMN and was applied as the more sensitive single-point screen (assay sensitivity ~100 nM BLVRB)

ENL R16 is surrounded by several CRBN residues in the N-terminal domain (F102, F150, I152) and stacks between CRBN F102 and F150, whose relative positions suggest formation of a cation- interaction (Fig

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc

The majority of modern fillers are formulated with hyaluronic acid (HA), a substance the body produces naturally to keep skin hydrated and supple