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DSIP has more human data, but that data is old, inconsistent, and methodologically limited

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Leading brands are increasingly expanding distribution into mainstream retail, reflecting growing demand for clinically informed products that cover hormone support and comprehensive wellness for example, Lemme expanded its nationwide retail presence at Walmart in January 2026

221 Clinically, they are used for long-term treatment of chronic inflammatory lung diseases such as COPD

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Although randomized controlled trials are still needed, clinical experience points to a promising therapeutic horizon for women with lipedema, through a transdisciplinary approach that integrates pharmacological treatment, physiotherapy and exercise, nutritional therapy, psychological support, and aesthetic or surgical procedures.37,39 Long-term use of diuretics is discouraged because they do not address the underlying inflammatory processes