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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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After radiotherapy, tumor cells showed typical ferroptosis morphological changesmitochondria were concentrated, membrane density increased, and mitochondrial ridges decreased ( Hepatocellular Carcinoma Hepatocellular carcinoma (HCC) is one of the malignant tumors that cause a serious global burden of disease, ranking sixth among the most common cancers and second among cancer-related deaths ( - and GPX4 and affecting the activity of system Xc - or GPX4 can induce ferroptosis of liver cancer cells ( - , thereby inducing ferroptosis of liver cancer cells ( Sorafenib, as a first-line drug for advanced HCC, has been proven to induce ferroptosis in HCC cells

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KPC cell xenograft mouse models were approved by the IACUC at Changhai Hospital

High-dose application of therapeutic agents such as antibiotic drugs during EVMP demands biomonitoring tools to assess the tissue concentration of the drug