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Asano N, Yoshida A, Ichikawa H et al

Compared to the HA microspheres, the modification of zinc (ZnHA) enhance insulin adsorption capacity and strontium (SrHA) promotes stromal cell proliferation

And, they reverse the hypermethylation of CpG islands in the promoter region of tumor suppressor gene by upregulating genes that are methylated due to fibrosis, such as the RASAL1 gene ( However, the disadvantages of 5AC and DAC are becoming increasingly apparent

Cp deficiency and mutations in copper-transporting genes such as ATP7B can cause abnormal metal distribution in the brain and induce (or exacerbate) neurodegenerative processes, including PD (168)