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Ineffective therapy was observed for antibodies targeting CD44v6, but a pharmacological inhibitor AMC303 and anti-CD44v6 CAR-T cells have demonstrated exemplary safety

Clinical role of Asct2 (Slc1a5) in kras-mutated colorectal cancer

identified a non-inhibitory aptamer against the CRL2ZYG11B complex, employing it as an E3 warhead to construct dual-function ZATACs capable of degrading multiple targets, e.g., HaloTag ( Halo-ZATAC#T3 ) (Fig

Metabolomics analysis of the 3D L-02 cell cultures revealing the key role of metabolism of amino acids in ameliorating hepatotoxicity of perfluorooctanoic acid

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The Cagrilintide family of peptides affects appetite and metabolic rate through amylin receptor agonism