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In addition, the use of AKT inhibitors in combination with extracellular asparagine (ASN) depletion can significantly inhibit tumor growth (Fig

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Neuron-specific SQOR overexpression has been shown to decrease the volume of cerebral infarction after stroke ( 2 S with hydroxocobalamin protects mitochondrial function in ischemic brain tissue by preventing H 2 S from inhibiting Complex IV ( 2 S and generates thiolate anions, significantly alleviating ischemic brain injury in mice ( 2 S production has proven beneficial: for example, oral metronidazole (to eliminate H 2 S-producing gut microbes) or a low-sulfur diet reversed neuro-metabolic abnormalities in SQOR-deficient mice (Figure 3 illustrates the diverse roles of SQOR in several systemic diseases

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doi: 10.3892/etm.2022.11536 168 PohlKMoodleyPDhandaA

In summary, the Keap1-Cul3 E3 ligase complex regulates the levels and activity of NRF2 through ubiquitination and degradation mechanisms