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Weighted gene co-expression network analysis (WGCNA) identified genotype-driven, rather than treatment-driven, gene modules, highlighting distinct transcriptional architectures between WT and KO animals

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Animal studies indicate dose-dependent effects, with toxic doses possibly affecting copper metabolism or interacting with embryonic development in hypersensitive models, warranting caution during pregnancy

However, it is unclear why genistein upregulates the levels of Nrf2 in the myocardium

A randomized trial of Iscador in advanced non-small cell lung cancer patients receiving carboplatin-based chemotherapy found that those receiving Iscador were less likely to need a chemotherapy dose reduction and experienced less frequent side effects and hospitalizations (Bar-Sela 2013)