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Particularly, human antigen R (HuR), an RBP protein encoded by the ELALVL1 gene, is well characterized to bind AREs transcripts [36] and might play a pivotal role in xCT mRNA stability through its binding to xCT 3'-UTR end, augmenting its stability, and protecting it from rapid degradation by exonucleases and by these means increasing the transporters translation [37]

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PMCID: PMC3074764

doi: 10.1371/journal.pone.0154419 3 HuangHXieWGengYFanYZhangZ