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[DOI] [PMC free article] [PubMed] [Google Scholar] Suzuki Y, Rani S, Liesenfeld O, Kojima T, Lim S, Nguyen TA, Dalrymple SA, Murray R, Remington JS

Graphical Abstract Keywords Acetaminophen, Caspase-1, Drug-induced liver injury, Inflammasome, NOD-, LRR-, and pyrin domain-containing 3, NLRP3 Introduction Acetaminophen (APAP), commonly known as paracetamol, is a widely used over-the-counter medication renowned for its analgesic and antipyretic properties

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GSH activity is facilitated by activation of the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 that regulates expression of genes controlling antioxidant, inflammatory and immune system responses

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Results: 194 patients (63.4% male, median age 55.6, on entecavir for a median of 47.2 mo) were recruited