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Health authorities in several countries, such as Australia and New Zealand, have taken steps to restrict its availability, classifying it as a prescription-only medicine despite it not being a legitimately prescribed product

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That distinction matters more than most people realize

The transdermal route promotes a more consistent and stable distribution of Estradiol than oral administration

Lancet 339, 943946.Google Scholar Rowland, I (1991) Nutrition and gut flora metabolism