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Thats not me denying it definitely doesnt cause an issue in some people, but right now we dont have evidence to support a mechanism in which it would happen

Three publicly available databases of biotinidase variants are accessible online: the Leiden Open Variation Database ( ClinVar ( and Biotinidase Deficiency and BTD , hosted by ARUP Laboratories ( Over 200 biotinidase variants are consolidated in the ARUP database, with more than 150 categorized as pathogenic

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The filtrate was evaporated under a gentle stream of nitrogen (on ice and protected from light and stored at 4 C) and protected from light in an aluminum-covered container, which provided the dry extract as residue