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Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

Are There Any Side Effects or Risks

Nono Nankam, Olah Hakim, Louise M

doi: 10.3389/fmicb.2025.1733315 Received 27 October 2025 Revised 04 December 2025 Accepted 05 December 2025 Published 16 December 2025 Volume 16 - 2025 Edited by Xiaoyuan Wei, University of South Florida, United States Reviewed by Chung-Yao Yang, Hygeia Touch Inc., Taiwan Milena Camargo, Centro de Tecnologa en Salud (CETESA)-Innovaseq SAS, Colombia Jhommara Bautista, University of the Americas, Ecuador Updates Copyright 2025 Feng, Song, Ren, Xu, Li, Feng and Wang

Downstream signaling pathways are overactivated when the KRAS gene is mutated, stimulating the production of angiogenic factors and promoting the growth of new blood vessels