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An in vitro study demonstrated that Leishmania sphingolipid-1 (LSPL-1) has cytotoxic effects and induces apoptosis in murine and human melanoma cells (B16F10 and A375 cell lines) by regulating the mitochondrial death pathway and generating reactive oxygen species

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In theory, an increase in the cytosolic Ca 2+ concentration of an erythrocyte may be the consequence of Ca 2+ influx from the extracellular space, decreased Ca 2+ transport from the cytosol to the extracellular space, or release from intracellular Ca 2+ binders

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doi: 10.1016/j.neurol.2014.03.010 44

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