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Nrf2-AKT interactions regulate heme oxygenase 1 expression in kidney epithelia during hypoxia and hypoxia-reoxygenation

Crescenz VA Medical Center in Philadelphia, and the University of Pennsylvania School of Medicine, tested a new and noninvasive way of delivering GSH through nasal sprays, and used proton magnetic resonance spectroscopy ( 1 H-MRS) to measure CNS uptake of GSH

FS-288 vs FS-315 Isoform Binding Differences Surface plasmon resonance experiments confirmed that the Kd of FS-288 for activin A was approximately 46.5 pM versus 432 pM for FS-315 a nearly 10-fold difference in binding affinity