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Moreover, ALS is often further characterized by dysregulated proteostasis and autophagy, which can cause an excess of unfolded proteins, including stress granules, and TDP-43 pathologies

Development and function of IL-10 IFN-gamma-secreting CD4(+) T cells

Jaakola, 2013

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As expected for a split protein, synthetic split-l- and d-DAM21 showed a lower melting temperature ( T m ) around 45 C as compared to the recombinant (non-split) version (~78 C) (Figs