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Unlike the previously mentioned study, significant toxicity was observed in the liver, lung, and kidney at doses of 200 and 500 mg/kg

Additionally, many herbs have insufficient research in humans to confirm potential interactions and side effects ( Ingredients that may become toxic over time or at high doses One concern with consuming vitamins and minerals through supplements rather than from foods is the increased risk of consuming an amount thats too high or could become toxic over time

Cantarovich M, Besner JG, Barkun JS, Elstein E, Loertscher R

JCI Insight 2 , e88735 (2017)

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The exogenous induction of GSH depletion causes mitochondrial-dependent apoptosis in CYP2E1-expressing HepG2 cells (E47 cells) [123]