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Target Gene full name : Glutamate-cysteine ligase, catalytic subunit Protein function Catalytic subunit of the enzyme initiating glutathione synthesis

Gene expression signatures of C1-27 and GSTO1 knockdown To identify pathways regulated by GSTO1 and to understand the mechanism of its antiproliferative effects, we used the nascent RNA Bru-seq method 27 to profile gene expression changes that occur in response to GSTO1 knockdown and inhibition

Assessment of thyroid function and oxidative stress state in foundry workers exposed to lead

Overexpressed xCT was responsible for the reduction in eumelanin formation in melanocytes and increased production of pheomelanin in the sheep wool, where brown/yellow patches were observed [91]

Results Treatment protocol This cohort of eight female and one male pwCF, median age 32 years (range 2246 years), were the first nine patients treated with compassionate phage therapy because of MDR (seven patients) or PDR (two patients) PsA that did not respond to standard cystic fibrosis (CF) therapies (Table 1)

However, further investigations are needed