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Itaconate promotes tumor growth via oxidative phosphorylation-driven ROS generation in peritoneal tissue-resident macrophages and concomitant ROS-mediated mitogen-activated protein kinases (MAPKs) activation in tumor cells (79)

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suggest that the improvement in insulin parameters could be due to the inhibition of COX-2 expression, P-selectin, or inflammatory cytokines such as TNF- and IL-1

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