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Waist circumference reductions were also dose-dependent for Cagrilintide, notably at 1.24.5 mg, exceeding those in the placebo group and approximating the reductions seen with liraglutide 3.0 mg

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In all KO genotypes, cFos induction in the AP and NTS was markedly blunted compared to WT mice, establishing that both AMY1R and AMY3R are necessary for transmitting cagrilintides central effects