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The regulation of COX2 expression is complex, involving transcriptional and post-transcriptional mechanisms influenced by cytokines, growth factors, and pro-inflammatory stimuli (225)

The lens fiber cell cytoskeleton Microtubules are abundant beneath the plasma membranes of lens fiber cells where they probably play an important role in stabilizing the fiber cell membrane

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By analyzing the impact of PTMs, such as phosphorylation, ubiquitination, and acetylation, as well as DNA methylation, histone modifications, and non-coding RNA interactions on NRF2 stability, activity, and expression, the study reveals the complex cellular protection network mediated by NRF2