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[13] Early clinical trials showed that the peptide had to be injected about ten times a day due to its short half-life, so the company collaborated with Southern Research in the US to develop a depot formulation that would be injected under the skin, and release the peptide slowly

Topical treatment strategies for non-melanoma skin cancer and precursor lesions

The most commonly documented side effects include nausea (~40% of subjects), flushing, headache, and a transient increase in systolic blood pressure

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It belongs to the class of neuroactive peptide hormones targeting melanocortin receptors, particularly MC4R and MC3R