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p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

doi: 10.1093/pcp/pci225 18 DietzenC.KoprivovaA.WhitcombS

This condition affects multiple organs, including the skin, liver, gastrointestinal tract, lungs, kidneys, thymus, lymph nodes, bone marrow, and central nervous system, and is categorized into grades I-IV according to its severity, typically manifesting weeks to months post-HSCT

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1 Bioactive molecules like schisantherin A modulate apoptosis-related proteins and increase the expression of neuroprotective molecules like heme oxygenase 1 (HO-1)