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JCI Insight 2(7):e90777 Lill R, Dutkiewicz R, Freibert SA, Heidenreich T, Mascarenhas J, Netz DJ, Paul VD, Pierik AJ, Richter N, Stmpfig M, Srinivasan V, Stehling O, Mhlenhoff U (2015) The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron-sulfur proteins

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Oxidative stress is an overload of oxidants and free radicals, mainly reactive oxygen species (ROS) such as superoxide radical anion (O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (HO ), and reactive nitrogen species (RNS) including nitric oxide (NO) and peroxynitrite (ONOO ), due to increased production and/or compromised antioxidant defenses

doi: 10.1016/j.biotechadv.2023.108248 5 AhmarS.UsmanB.HenselG.JungK.-H.GruszkaD