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Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells

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The best-known example is the regulation of the synthesis and regeneration of glutathione (GSH), which is the most abundant antioxidant molecule in cells

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Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro

Pectin can prevent such diabetic complications caused by increased RAGE expression and activating ligands by reducing postprandial blood glucose levels, acting as a prebiotic to improve glucose tolerance and insulin sensitivity and providing antioxidant protection against oxidative stress