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These autoantibodies form immune complexes that deposit in various tissues and organs, leading to organ damage

To date, there is no promising treatment other than symptomatic treatment involving the use of topical keratolytic agents, moisturizers, emollients, or retinoids to hydrate the skin and prevent itching and scaling or mechanical scale removal (Oji et al

Tailford LE, Crost EH, Kavanaugh D, Juge N (2015) Mucin glycan foraging in the human gut microbiome

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of the preamble of this proposed rule, beginning with the new technology add-on payment applications for FY 2025, we are proposing, for technologies that are not already FDA market authorized, to require applicants to have a complete and active FDA market authorization request at the time of new technology add-on payment application ( submission, and to provide documentation of FDA acceptance or filing to CMS at the time of application submission