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This is mechanistically different from GLP-1 receptor agonists like semaglutide or tirzepatide, which are large peptide chains stabilised by complex tertiary structures that degrade slowly even at suboptimal temperatures

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It also exibits questionable behaviour in the presence of UV light and was the center of a debate between the non-profit group, EWG (whose intentions are no doubt good, but its credibility is often questioned by scientists) and a group of scientists and dermatologists lead by Steven Q

Funding This work was supported by the German Research Foundation (DFG) via the SFB/TRR205 (KF, SRB, AE-A, WT), the IRTG-2251/2 (NB, MT, KF, SRB, AE-A, WT), the IRTG-3019/1 (SRB, WT), and the Else Krner Fresenius-Stiftung (WT, 2025_EKES.07)

When toxic burden is high, toxins recirculate, detox pathways get overwhelmed, and inflammation keeps the system from moving forward

Dong S, Xu J, Jia T, Xu M, Zhong C, Yang G, et al