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Although NHL has been declining in adults since the 1990s (due to the reduction of AIDS cases), it has recently been rising in children at a rate of 1% per year in males and 1/2% in females

Age-related increases in basal ganglia glutamate are associated with TNF-alpha, reduced motivation and decreased psychomotor speed during IFN-alpha treatment: Preliminary findings

Research also suggests it may contribute to underlying processes such as inflammation, oxidative stress and damage to blood vessels