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This characteristic makes protocol adherence particularly important for researchers seeking reliable data

This group of cells is often implicated in inflammatory and degenerative disorders of the brain ( Classically the study of demyelination in disease has focused on oligodendrocytes, as those cells are primarily affected, but recent literature has shown an emerging role of other glial cells, particularly astrocytes and microglia, in regulating not only myelination but also neuroinflammation and neuroplasticity in the course of the disease ( As different mechanisms at a cellular level may be the cornerstone of developing more accurate biomarkers and effective DMTs, it is imperative to study the different influences which glial cells may exert in primary demyelinating phenotypes

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Recent Mendelian randomization findings further validate this framework: Dorea and Sellimonas appear protective, whereas Phascolarctobacterium and Ruminococcaceae UCG-004 are associated with increased PTSD risk (He et al., 2024)

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