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Current evidence, however, has linked kidney malfunction, reflected by a fall of the estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73 m 2 (termed a low eGFR) with urinary Cd excretion of 0.27-0.32 g/g creatinine [7,8] , which are much lower than the JECFAs and the EFSAs threshold levels mentioned above