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Using these techniques in multiple contexts (e.g., dose responses of ligand, multi-ligand stimulation, acute infection) will help us tease apart how signaling changes with these different parameters, creating a more complete model of NF-B signaling responses and transcriptional regulation

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Cortisol affects neuronal mitochondrial function in a biphasic manner : Low, normal levels of cortisol increase mitochondrial function Chronically high levels of cortisol decrease mitochondrial function.[ref] Chronic stress alters cortisol levels and thus can affect mitochondrial function in the brain

Martin-Nizard, F

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