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[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Cho H.J., Bae W.J., Kim S.J., Hong S.H., Lee J.Y., Hwang T.-K., Choi Y.J., Hwang S.Y., Kim S.W

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BPC-157 + TB-500, for the cartilage indication Due to the emerging chondroprotective profile of AOD-9604 (Vukmirovic-Popovic 2010), the research literature features the combination with BPC-157 and TB-500 for indications: Osteoarthritis (intra-articular formulation) Tendinopathy Chondral defects in animal models MOTS-c, metabolic support MOTS-c improves mitochondrial efficiency, released fatty acids from AOD-9604-induced lipolysis can then be more efficiently oxidized

These processes can impair neuronal communication, disrupt synaptic plasticity, and contribute to mitochondrial dysfunction, a key factor in cellular energy production