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Overexpression of MMPs can result to excessive ECM breakdown, contributing to the pathogenesis of various respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, acute respiratory distress syndrome (ARDS) and pulmonary fibrosis [37,38,39,40]

Current perspectives suggest a bidirectional interaction between peripheral immune activation and central inflammation: peripheral inflammation can enhance intracerebral inflammation via the BBB or vagal nerve pathways, while central inflammation can, in turn, stimulate the peripheral immune system (Shin et al., 2022

After exposure to immunostimulants, there is an enhancement of cytokines in the fetal brain and maternal serum, amniotic fluid and placenta (Urakubo et al., 2001)

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Experimental studies demonstrate curcumin alleviates oxaliplatin-induced neuropathic pain by suppressing oxidative stress-mediated NF-B activation and subsequent inflammation (Zhang et al., 2020b)

But if the underlying cause of your injury is still present (like repetitive overuse or biomechanical issues) symptoms may gradually return