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10.1002/hep.28696 Hepatology

Reville PK, MD, MPH, Kantarjian H, MD, Borthakur G, MD, Pemmaraju N, MD, DiNardo CD, MD, MSCE, Sasaki K, MD, PhD, Daver N, MD, Issa GC, MD, Ohanian M, DO, Montalban-Bravo G, MD, Short NJ, MD, Jain N, MD, Bhalla KN, MD, Jabbour EJ, MD, Ferrajoli A, MD, Takahashi K, MD, PhD, Rausch CR, PharmD, Malla R, RN, BSN, Marek K, Brandt M, BS, Popat UR, MD, Andreeff M , MD, PhD, Garcia-Manero G, MD, Konopleva M, MD, PhD, Ravandi F, MBBS, Kadia TM, MD

303.Janaki S

This might be due to the chronic exposure to high ROS concentrations of these cells

Tests in bacteria, cells, and mice all came back negative, suggesting the compound does not pose carcinogenic risk through DNA damage mechanisms

Recent studies have elucidated potential mechanisms of chemotherapy-induced ovarian damage, including DNA damage, oxidative stress, mitochondrial dysfunction, and apoptotic signalling abnormalities induced by cisplatin and other chemotherapeutic agents (8, 9)