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Redox changes and cellular senescence in Alzheimers disease

High-dose heavy metals exposure, particularly mercury and lead, may induce severe complications such as abdominal colic pain, bloody diarrhea, and kidney failure (Bernhoft, 2012

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Subsequent work proved that IGF-I was a potent stimulus for osteoclast differentiation, 61 suggesting that IGF-I was a coupler of bone remodeling