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6 Future directions and conclusion 6.1 Future directions The complexity of CRHM syndrome, which arises from the interplay of chronic inflammation, insulin resistance, lipotoxicity, oxidative stress, and neurohormonal dysregulation across the cardiovascular, renal, hepatic, and metabolic systems, calls for innovative, integrated therapeutic strategies

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Cell-penetrating peptides represent another category of direct-acting therapeutic agents

IV Hydration & Recovery Proper hydration is critical for long COVID recovery, yet many patients stay chronically dehydrated because of dysautonomia and other complications

In addition, in an attempt to have a dual drug-prodrug mechanism of action, a melatonin-SFN hybrid has been designed, which demonstrated to induce neuroprotection in cortical neurons subjected to OS [293]