Hepatology 47 , 455460 (2008)
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Furthermore, the accompanying paper shows that deletion of glucose-6-phosphate dehydrogenase (G6PD) and malic enzyme (ME1), both of which drives NADPH production and antioxidant defence, also increases ROS-dependent ADM (Radyk et al., manuscript in press).Taken together, these results underline the importance of controlling ROS levels in acinar cells of the pancreas
Confounding factors such as prolonged antibiotic use and PPI (proton pump inhibitor) administration can further alter the composition of gut microbiota, a phenomenon that is prevalent in viral hepatitis patients complicated with spontaneous bacterial peritonitis and gastroesophageal reflux disease
In high fat diet (HFD) and streptozotocin (STZ)-induced type 2 diabetic mice model and HK-2 cells, after treatment with metformin (200 mg/kg/d) for 24 weeks, some indicators of mitophagy (LC3II, Pink1, Parkin, Atg5) were examined
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