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3 Pernicious anemia also presents with hemolysis, which is due to the breakdown of abnormal and fragile RBC precursors leads to intramedullary hemolysis and resulting abnormalities in hemolysis tests

Carnesecchi J, Malbouyres M, de Mets R, et al

Differential expression analysis was conducted using pyDESeq2 (ref

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Coll Relat Res 5(4):355368 Shoolingin-Jordan PM, Al-Daihan S, Alexeev D, Baxter RL, Bottomley SS, Kahari ID, Roy I, Sarwar M, Sawyer L, Wang SF (2003) 5-Aminolevulinic acid synthase: mechanism, mutations and medicine

However, while 16 days of L-citrulline supplementation at a daily dose of 3.4 g significantly increased plasma citrulline, arginine, and nitrite levels, and increased muscle oxygenation during moderate-intensity (70% VO 2 peak) exercise, there were no superior effects on time-to-exhaustion during high-intensity (90% VO 2 peak) exercise