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Oral administration of myricetin significantly reduces Fe 2+ levels in the substantia nigra of PD rats, inhibits neuronal ferroptosis, decreases ROS production, downregulates malondialdehyde (MDA) and -synuclein (-Syn) expression, elevates GSH levels, and ameliorates motor deficits

In addition, the age of onset is quite wide, even if most cases have onset in infancy

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Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(ALPHA) Subunit expression that correlate with enhanced tau phosphorylation