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Bustillo JR, Chen H, Jones T, Lemke N, Abbott C, Qualls C, et al

Longer binding times may result in more effective binding

Thats because Hashimotos generally causes slow, subtle changes to the thyroid gland over the course of many years, which suggests that the TPO antibodies that characterize Hashimotos are not likely to be causing symptoms

The application time was either at 20 min after L-NAME administration (as early therapy) or at 48 h after L-NAME administration (as delayed therapy)

Dosing interval also varies by age (Table 1)

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