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Histone reductions occur in response to factors inducing cell senescence If histones were indeed reduced in irradiated cells that became senescent, then it would stand to reason that such reductions would also be expected to accompany cellular senescence triggered by other stimuli

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Methods Enzymol Basel Verlag Chemie 1983;3:258-65

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Limited Long-Term Research There is still limited long-term data on the safety of AOD-9604, especially with extended use