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This indicated that, along with an overall decrease in TG synthesis, specific pathways/enzymes involved in polyunsaturated fatty acid (PUFA) synthesis may be stimulated in the livers of KO mice

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Indeed, owing to its ability to activate the tolerogenic pathway of tryptophan catabolism via the immunoregulatory enzyme indoleamine 2,3-dioxygenase 1 (Puccetti and Grohmann, 2007), T1 specifically potentiates immune tolerance in the lung, breaking the vicious circle that perpetuates chronic lung inflammation in response to a variety of infectious noxae (Romani et al., 2006)

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