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Despite its ubiquity and recognized safety when taken within recommended doses, APAP overdose remains a significant public health concern worldwide due to liver injury, posing a substantial burden on healthcare systems and contributing to a considerable number of hospitalizations and fatalities annually

Abstract Chisholm, A.D

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This pathway begins with the accurate determination of the methylation status of key gene promoters (such as NIS and TSHR) in tumor tissues or circulating tumor DNA (ctDNA) using high-sensitivity techniques such as pyrosequencing or methylation-specific PCR [140, 141]