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Description

Li, Y., Lam, F., Clifford, B

In the classic db/db mouse model of metabolic fatty liver, oral administration of betaine can inhibit the interaction between forkhead box protein O6 and peroxisome proliferator-activated receptor gamma (PPAR), inhibit the expression of primary lipogenic genes, such as fatty acid synthase (FAS) and acetyl-CoA carboxylase, and reduce hepatic lipid accumulation (77, 78)