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Frontostriatal circuitry and the tryptophan kynurenine pathway in major psychiatric disorders

Overexpression of FSP1 in GPX4 knockout cells can also significantly reduce phospholipid peroxidation products, thereby inhibiting the occurrence of ferroptosis, demonstrating that the anti-ferroptosis effect of FSP1 does not depend on the expression of GPX4

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459,460,461 Clinical studies show that 47% of elderly heart failure patients have reduced transferrin saturation, and low transferrin saturation is independently linked to a higher risk of all-cause death